Embryo survival gene may fight range of diseases - study

HONG KONG Mon Nov 26, 2012 3:41pm IST

Related Topics

Rajalakshmi (C), 28, smiles after winning the Miss Wheelchair India beauty pageant in Mumbai November 26, 2014. REUTERS/Danish Siddiqui

Miss Wheelchair India

Seven women from across India participated in the country's second wheelchair beauty pageant, which aims to open doors for the wheelchair-bound in modelling, film and television, according to organisers  Slideshow 

HONG KONG (Reuters) - A gene that keeps embryos alive appears to control the immune system and determine how it fights chronic diseases like hepatitis and HIV, and autoimmune diseases like rheumatoid arthritis, scientists said on Monday.

Although the experts have only conducted studies on the gene Arih2 using mice, they hope it can be used as a target for drugs eventually to fight a spectrum of incurable diseases.

Lead author Marc Pellegrini at the Walter and Eliza Hall Institute of Medical Research in Australia said the gene appears to act like a switch, flipping the immune system on and off.

"If the gene is on, it dampens ... the immune response. And if you switch it off, it greatly enhances immune responses," Pellegrini said in a telephone interview.

"It is probably one of the few genes and pathways that is very targetable and could lead to a drug very quickly."

Arih2 was first identified by another group of scientists in the fruit fly but it drew the interest of Pellegrini's team because of its suspected links to the immune system.

In a paper published in Nature Immunology, Pellegrini and his team described how mice embryos died when the gene was removed.

Next, they removed the gene from adult mice and noticed how their immune systems were boosted for a short period of time. But it quickly went into an overdrive and started attacking the rodents' own healthy cells, skin and organs.

"The mice survived for six weeks quite well. Then they started developing this very hyperactive immune responses and if you leave it for too long, it starts reacting against the body itself," Pellegrini said.

Pellegrini and his colleagues hope that scientists can study the gene further and use it as a drug target to fight a large spectrum of diseases.

"It's like an accelerator. In infectious diseases, you want to slam on the brakes on this gene, and for autoimmune diseases, you want to push the accelerator to make it work much harder to stop the whole immune response," said Pellegrini.

"The more the gene works, the less of an immune response there is. And the less active the gene is, the more the immune response is."

(Reporting by Tan Ee Lyn; Editing by Nick Macfie)

FILED UNDER:

REUTERS SHOWCASE

Ferguson Riots

Ferguson Riots

Streets of Ferguson quiet after two nights of racial unrest.  Full Article 

Sedition Act

Sedition Act

Malaysia to retain and prop up Sedition Act, says PM.  Full Article 

Hong Kong Protests

Hong Kong Protests

Hong Kong student leader banned from Mong Kok protest site.  Full Article 

Poll Pushed Back

Poll Pushed Back

Thai election pushed back to 2016 - deputy PM.  Full Article 

Taiwan Election

Taiwan Election

Taiwan vote tests waters for pro-China govt ahead of presidential polls  Full Article 

Rakhine Plight

Rakhine Plight

Exclusive - Poor and besieged, Myanmar's Rakhine join Rohingya exodus  Full Article 

Ebola Outbreak

Ebola Outbreak

Ebola vaccine from Glaxo passes early safety test  Full Article 

Korea Ferry Crew

Korea Ferry Crew

Stigma and isolation haunt S.Korean families of convicted ferry crew  Full Article 

Zero Tolerance

Zero Tolerance

China takes "zero tolerance" approach to regional polluters: Cabinet.  Full Article 

Reuters India Mobile

Reuters India Mobile

Get the latest news on the go. Visit Reuters India on your mobile device  Full Coverage