'Intelligent' surgical knife can sniff out cancer tissue

LONDON Wed Jul 17, 2013 11:54pm IST

1 of 3. Julia Balog of Imperial College London demonstrates the Intelligent Knife on a piece of meat at St Mary's Hospital in London July 17, 2013.

Credit: Reuters/Luke MacGregor

Stocks

   

LONDON (Reuters) - Scientists have created an "intelligent" surgical knife that can detect in seconds whether tissue being cut is cancerous, promising more effective and accurate surgery in future.

The device, built by researchers at London's Imperial College, could allow doctors to cut back on additional operations to remove further pieces of cancerous tumors.

The technology, effectively merging an electrosurgical knife that cuts through tissue using heat with a mass spectrometer for chemical analysis, has also been shown to be able to distinguish beef from horsemeat.

Surgeons often find it impossible to tell by sight where tumors end and healthy tissue begins, so some cancer cells are often left behind. A fifth of breast cancer patients who have lumpectomy surgery need a second operation.

The new "iKnife" is designed to get round the problem by instantly sampling the smoke given off as tissue is cut through using an electric current to see if it is cancerous.

In the first study to test the device in patients, the iKnife diagnosed tissue samples from 91 patients with 100 percent accuracy, researchers at Imperial College London reported in Science Translational Medicine on Wednesday.

Currently, removed tissue can be sent for laboratory analysis while the patient remains under general anesthetic - but each test takes around half an hour, while the iKnife provides feedback in less than three seconds.

It does this by analyzing biological information given off from burning tissue and comparing the findings to a database of biological fingerprints from tumors and healthy tissue.

"It's a really exciting innovation and a very promising technique for all types of surgery," said Emma King, a head and neck surgeon at Southampton Hospital, England, who was not involved in the research.

Still, she now wants to see how the iKnife performs in a randomized clinical trial.

CLINICAL TRIAL

Zoltan Takats of Imperial College, who invented the device, said he aimed to test it in such a study, involving between 1,000 and 1,500 patients with various types of cancers.

That trial process is likely to take two or three years and only then will the iKnife be submitted for regulatory approval, paving the way for its commercialization.

Takats has founded a Budapest-based company called MediMass to develop the product and he expects to strike a partnership deal with a major medical technology company to bring it to market in North America and Europe.

Hi-tech surgical equipment is being used increasingly in modern hospitals to help surgeons do a better job, most notably with the da Vinci surgical robot from Intuitive Surgical.

The current experimental version of the iKnife cost Takats and colleagues at Imperial around 200,000 pounds ($300,000) to build. Takats said the price would come down once it entered commercial production.

The research was welcomed by health minister Lord Howe, who said it could benefit both patients and the health service by reducing the number of people needing secondary operations for cancer.

The iKnife may also have a place beyond cancer, according to Takats, since it can identify tissue with an inadequate blood supply, as well as types of bacteria present in tissue. ($1 = 0.6613 British pounds)

Health

REUTERS SHOWCASE

Lakhvi's Bail

Lakhvi's Bail

Pakistan court bails man accused of masterminding Mumbai attack.  Full Article 

Mass Stabbing

Mass Stabbing

Eight children killed in Australia in reported mass stabbing.  Full Article 

PM's Moves

PM's Moves

Modi moves in to speed up $300 billion stuck projects.  Full Article 

Coal Unions

Coal Unions

Coal India workers threaten five-day strike, stokes output worries.  Full Article 

Space Programme

Space Programme

ISRO tests its heaviest space launch vehicle, eyes global market.  Full Article 

Peshawar attack

Peshawar Attack

Some Pakistan militants denounce school attack, amid national outrage.  Full Article 

Uber Again

Uber Again

Uber driver in Boston charged with kidnapping and rape.  Full Article 

Discounts

Discounts

Dealers offer gold discount for first time in five months.  Full Article 

"PK" in Cinemas

"PK" in Cinemas

Secret of year's "biggest" Bollywood film is its plot.  Full Article 

Reuters India Mobile

Reuters India Mobile

Get the latest news on the go. Visit Reuters India on your mobile device   Full Coverage