Tarceva helps slow lung cancer progression-study

* 29 pct reduction in risk of disease progression

* Progression-free survival 4.8 months vs 3.7 months

By Bill Berkrot

NEW YORK, May 30 (Reuters) - The combination of cancer drugs Tarceva and Avastin delayed the worsening of advanced lung cancer following chemotherapy longer than Avastin alone, according to results from a clinical trial.

The study was designed to test Tarceva as a so-called maintenance therapy to help delay progression of the disease following successful chemotherapy treatments. Tarceva, which is co-marketed by U.S. biotech company OSI Pharmaceuticals Inc (OSIP.O: Quote, Profile, Research)and Swiss drugmaker Roche Holding AG (ROG.VX: Quote, Profile, Research), is currently approved to treat advanced lung cancer after at least one prior therapy has failed.

"It's fairly unequivocal in my mind that the Avastin/Tarceva combination is superior to either agent alone," Dr. Vincent Miller of Memorial Sloan-Kettering Cancer Center and one of the study's lead investigators said in an interview.

In the 768-patient Atlas study, there was a 29 percent reduction in the risk of disease progression for those patients treated with the Tarceva/Avastin combination compared to those who received Avastin plus a placebo, according to data presented Saturday at the American Society of Clinical Oncology (ASCO) meeting in Orlando, Florida.

The median progression-free survival -- the time it took for the cancer to get worse in half the patients -- was 4.8 months for the combination therapy versus 3.7 months for the placebo group, researchers said.

The study was halted early because the improvement in efficacy found in the Tarceva group was deemed to be statistically significant.