Experts identify genes for bird flu replication

HONG KONG (Reuters) - Scientists have identified around 100 genes that the H5N1 bird flu virus needs in a host in order to replicate, and this finding may help in the hunt for ways to block its proliferation.

"All viruses rely on host cell proteins and their associated mechanisms to complete the viral life cycle. Identifying the host molecules that participate in each step of virus replication could provide valuable new targets for antiviral therapy," they wrote in the latest edition of Nature magazine.

In their study, the experts from Japan, Indonesia and the United States infected fruit fly cells with genetically altered H5N1 virus.

The H5N1 virus needed slight modifications because fruit flies are normally not susceptible to influenza.

The experts also chose the fruit fly because it has a relatively small number of genes -- 14,000 -- making it easier for scientists to study.

"We found genes (proteins) that are important for influenza virus replication. We identified about 100 genes," said Yoshihiro Kawaoka, a leading virologist and bird flu expert at the University of Tokyo in Japan.

Of these, at least three existed in human cells.

"We took three and tested them and they were important for flu virus replication (in humans)," he told Reuters.

"I presume that many of the other genes we identified are also important for influenza virus replication in humans."