Some women can reduce breast cancer chemo: study

By Maggie Fox, Health and Science Editor

WASHINGTON (Reuters) - Many women with breast cancer may be able to safely skip at least one step in chemotherapy, saving themselves time and side-effects, U.S. researchers said on Wednesday.

Women in a study with so-called estrogen-receptor positive cancers did not gain any added benefit from taking Taxol, which can cause nausea, hair loss, severe hypersensitivity reactions and other side-effects.

But those with HER2-receptor-positive cancer -- about 15 to 20 percent of women with breast cancer -- were significantly helped when Taxol was added, Dr. Daniel Hayes of the University of Michigan and colleagues reported in the New England Journal of Medicine. They had a 41 percent lower rate of having their cancer come back.

"If you ask how much longer am I going to live disease free, it's about 3 years ... and that's huge," Donald Berry of the University of Texas M. D. Anderson Cancer Center, who helped direct the study, said in a telephone interview.

While they are not recommending any changes in practice yet, the researchers say doctors should be aware of their findings in discussing treatments with patients.

"In general, chemotherapy for breast cancer has been a one-size-fits-all approach," Hayes said in a statement.

Doctors usually add more chemotherapy agents if they believe the cancer is likely to have spread. Taxol, known generically as paclitaxel, or related drugs in a class called taxanes are usually added to a cocktail of other drugs.

The researchers had been studying a group of women for years, many of whom got Taxol after going through four cycles of the drugs adriamycin and cytoxan for breast cancer that had spread to their lymph nodes.