Experimental vaccine cures pre-cancer vulvar growths

By Gene Emery

BOSTON (Reuters) - An experimental vaccine cured nearly half of women with pre-cancerous growths on their genitals, producing major improvement in nearly four out of five, researchers in the Netherlands reported on Wednesday.

"We hope to get results like this in women with cancer, but those tests are in the future," team leader Dr. Gemma Kenter of Leiden University said in a telephone interview.

The vaccine is different from the Merck's Gardasil vaccine and GlaxoSmithKline's rival Cervarix, which are available to prevent cervical cancer caused by common forms of the human papillomavirus, known as HPV.

The new vaccine tested by Kenter and her colleagues is designed as a treatment for precursor growths known as vulvar intraepithelial neoplasia. Unlike Cervarix and Gardasil, it is designed to treat women who are already infected and already experiencing the growths.

"We tried to find something for women who already had the disorder," Kenter said.

More than 75 percent of the growths are caused by the HPV-16 virus and treatment with topical chemotherapy, laser, or surgery is often unsuccessful.

The vaccine was tested on 20 women. Lesions disappeared in nine of the women, including one whose growths were more than 10 years old.

Another six women saw their growths shrink by at least 50 percent after one year. One woman died of sudden heart failure before her 12-month evaluation.