Bird flu pandemic seen needing multiple drugs

By Ben Hirschler

LONDON (Reuters) - Governments need to stockpile different sorts of flu drugs -- not just Roche Holding AG's Tamiflu -- to counter the danger of resistance in a pandemic triggered by bird flu, British experts said on Wednesday.

The warning could boost demand for GlaxoSmithKline Plc's inhaled medicine Relenza, which has been largely overlooked in favour of Roche's more convenient pill.

Scientists analysing the structure of a key flu virus protein found that both H5N1 and seasonal flu could develop resistance to Tamiflu, while still remaining highly susceptible to Relenza.

"What this research shows is that stockpiling any one drug to prepare for a potential H5N1 pandemic is unlikely to provide adequate cover," said Steve Gamblin of the National Institute for Medical Research in London.

"In order not to be outflanked by the virus, it will be necessary to have stocks of both existing drugs."

There is a also "a huge imperative" to develop further drugs since the best way to treat patients in the long term is likely to be a three- or four-pronged approach, similar to the multi-drug cocktails used to fight HIV and AIDS, Gamblin said.

A new influenza drug, peramivir, is being developed by Biocryst Pharmaceuticals Inc but it must be injected and it has not performed well in clinical trials. Two older flu drugs are available but flu viruses have quickly developed resistance to them, although some experts believe they may be useful in cocktails with newer drugs.

Both flu viruses and HIV have a high rate of mutation, which allows them to adapt to the treatments devised to tackle them.