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UPDATE 2-AbbVie to seek approval for potential blockbuster leukemia drug
August 12, 2015 / 2:19 PM / 2 years ago

UPDATE 2-AbbVie to seek approval for potential blockbuster leukemia drug

(Adds analyst comment, ongoing studies in other blood cancers)

By Ransdell Pierson

Aug 12 (Reuters) - AbbVie Inc on Wednesday said its experimental treatment for a form of leukemia associated with a gene mutation met its main goal in a mid-stage trial and that the company would seek U.S. approval of the medicine, which analysts have said has blockbuster sales potential.

AbbVie, developing the drug venetoclax with Switzerland’s Roche Holding AG, said it would unveil data from the Phase II trial at an upcoming medical meeting and will seek U.S. marketing approval for the product this year.

The drug was tested in patients with chronic lymphocytic leukemia (CLL) who had a so-called 17p gene deletion that has been associated with aggressive cancer and survival of less than 2 to 3 years after diagnosis. The trial included patients with relapsed or advanced CLL, or those who had previously been untreated.

Venetoclax achieved its target overall response rate in the study, meaning it reduced the number of cancer cells by at least a predefined margin, the drugmakers said.

Brokerage Cowen and Co has predicted the medicine, if approved, could capture annual sales of $2 billion by 2020. It works by blocking BCL-2, a protein that prevents self-destruction of defective or cancerous cells in the body.

“Venetoclax may help restore the natural process that allows these leukemic cells to self-destruct,” Sandra Horning, Roche’s chief medical officer, said in a release.

Safety of the drug was similar to that seen in earlier trials, with no unexpected new issues, AbbVie said

The FDA earlier this year granted “breakthrough therapy” status to the drug for previously treated CLL patients with the gene deletion, a designation that can help speed regulatory review.

“Given the mechanism of the drug, it represents a strong candidate to be used across a range of blood cancers,” Deutsche Bank said in a research note on Wednesday. It is also being studied in non-Hodgkin’s lymphoma, acute myeloid leukemia and multiple myeloma.

Chronic lymphocytic leukemia is a slow-progressing blood cancer in which the bone marrow makes too many lymphocytes, a type of white blood cell. Almost 15,000 new U.S. cases are diagnosed each year.

About 3 to 10 percent of CLL patients have the 17p deletion when diagnosed, but it is found in 30 to 50 percent of patients who have relapsed or advanced disease, AbbVie said.

Abbvie shares fell 1 percent in morning trading, amid a 1.5 percent decline for the broad stock market. Roche shares fell 2.4 percent. (Reporting by Ransdell Pierson; Editing by Nick Zieminski)

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