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BRIEF-Argenx publishes seminal data supporting therapeutic potential of ARGX-110
December 29, 2016 / 6:18 AM / a year ago

BRIEF-Argenx publishes seminal data supporting therapeutic potential of ARGX-110

Dec 29 (Reuters) - Argen X BV :

* Argenx announces publication of seminal data supporting the therapeutic potential of ARGX-110 for acute myeloid leukemia in the Journal of Experimental Medicine

* Publication of new preclinical data on CD70/CD27 pathway that provide further rationale for ARGX-110 therapy for treatment of acute myeloid leukemia (AML)

* ARGX-110, a simple antibody targeting CD70, is currently being evaluated in a phase I/II study in combination with azacitidine in newly diagnosed AML patients

* Data demonstrate that CD70/CD27 is highly expressed on AML blasts and leukemic stem cells in newly diagnosed AML patients regardless of cytogenetic factors or patient’s risk class

* Data show CD70/CD27 pathway to be critical in biology of leukemic stem cells, and critical therapeutic intervention using a CD70-targeted antibody to enable selective targeting of leukemic stem cells without impacting hematopoietic stem cells, resulting in a survival benefit in preclinical AML models Source text for Eikon: Further company coverage: (Gdynia Newsroom)

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