Profile: AxoGen Inc (AXGN.OQ)

AXGN.OQ on NASDAQ Stock Exchange Capital Market

24 May 2019
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AxoGen, Inc., incorporated on June 20, 1977, offers surgical solutions for peripheral nerve injuries. The Company provides products and education to improve surgical treatment algorithms for peripheral nerve injuries. Its portfolio of products includes Avance Nerve Graft, AxoGuard Nerve Connector, AxoGuard Nerve Protector and Avive Soft Tissue Membrane. Along with these core surgical products, the Company also offers the AxoTouch Two-Point Discriminator, and AcroVal Neurosensory and Motor Testing System. These evaluation and measurement tools assist healthcare professionals in detecting changes in sensation; assessing return of sensory, grip and pinch function; evaluating treatment interventions, and providing feedback to patients on nerve function. Its portfolio of products is available in the United States, Canada, the United Kingdom and several European and other countries.

The Company's products are used by surgeons during surgical interventions to repair a range of nerve injuries throughout the body. These injuries range from a simple laceration of a finger to a complex brachial plexus injury (an injury to the network of nerves that originate in the neck), as well as nerve injuries caused by dental, orthopedic and other surgical procedures. Avance Nerve Graft provides surgeons an implant with the micro-architecture of a human nerve. This structure allows for bridging nerve gaps or discontinuities up to 70 millimeters (mm) in length.

Avance Nerve Graft

Avance Nerve Graft is intended for the surgical repair of peripheral nerve discontinuities to support regeneration across the defect (a gap created when the nerve is severed). It is intended to act as a bridge in order to guide and structurally support axonal regeneration across a nerve gap caused by traumatic injury or surgical intervention. Avance Nerve Graft is decellularized and sterile extracellular matrix (ECM) processed from human peripheral nerve tissue. The Company offers the Avance process, a method for processing recovered human peripheral nerve tissue in a manner that preserves the essential structure of the ECM, while cleansing away cellular and noncellular debris. Avance Nerve Graft consists of bundles of small diameter endoneurial tubes that are held together by an outer sheath called the epineurium. Avance Nerve Graft has been processed to remove cellular and noncellular factors, such as cells, fat, blood, axonal debris and chondroitin sulfate proteoglycans (CSPG), while preserving the three-dimensional laminin lined tubular bioscaffold (microarchitecture), epineurium and microvasculature of the peripheral nerve.

AxoGuard Nerve Connector

AxoGuard Nerve Connector is a coaptation aid used to align and connect severed nerve ends in a tensionless repair. The product is in a tubular shape with an open lumen on each end where the severed nerve ends are placed. It is used when the gap between the nerve ends is approximately five mm in length. AxoGuard Nerve Connector is made from a minimally processed porcine ECM, which allows the body's natural healing process to repair the nerve, while its tube shape isolates and protects the injured nerves during the healing process. During healing, the patient's own cells incorporate into the ECM product to remodel and form a tissue similar to the outermost layer of the nerve (nerve epineurium).

AxoGuard Nerve Protector

AxoGuard Nerve Protector is a product used to protect and wrap injured peripheral nerves, and reinforce reconstructed nerve gaps, while preventing soft tissue attachments. It is designed to protect and isolate the nerve during the healing process after surgery by creating a barrier between the nerve tissue and the surrounding tissue bed. The product is delivered in a slit tube format allowing it to be wrapped around nerve structures. AxoGuard Nerve Protector is made from a minimally processed porcine ECM. During healing, the ECM remodels, allowing the protector to separate the nerve from the surrounding tissue.

Avive Soft Tissue Membrane

Avive Soft Tissue Membrane is minimally processed human umbilical cord membrane. Avive Soft Tissue Membrane offers a resorbable anatomical covering to keep tissue surfaces apart.

AcroVal Neurosensory and Motor Testing System

AcroVal Neurosensory and Motor Testing System is a device for evaluating patients with peripheral nerve conditions. The AcroVal consists of various devices designed to evaluate hand strength and neurosensory function, which include AcroGrip for hand grip strength measurement; AcroPinch for pinch strength measurement, and Pressure-Specified Sensory Device (PSSD), which is a somatosensory evaluation and measurement device.

AxoTouch Two Point Discriminator

The AxoTouch Two-Point Discriminator tool can be used to measure the innervation density of any surface area of the skin. The discs are useful for determining sensation after a nerve injury, following the progression of a repaired nerve, and during the evaluation of a person with a possible nerve injury, such as nerve division or nerve compression. The AxoTouch Two-Point Discriminator tool is a set of two aluminum discs, each containing a series of prongs spaced between 2 to 15 mm apart. A circular depression on either side of the disc allows ease of rotation. The discs can be rotated between a single prong for testing one-point and any of the other spaced prongs for testing two-point intervals.

The Company competes with Integra LifeSciences Holding Corporation, Baxter International, Inc. and Stryker Corporation.

Company Address

AxoGen Inc

13631 Progress Blvd Ste 400
ALACHUA   FL   32615-9409
P: +1386.4626817
F: +1386.4626801

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